Research uncovers new information surrounding radiation
Feb 17, 2012
New research developed by the Department of Radiation Oncology at UCLA's Jonsson Comprehensive Cancer Center found that radiation treatment for breast cancer patients kills off half of all tumor cancer cells along with transforming the other half into cancer cells, which is why radiation is not as effective. With this knowledge, scientists may be able uncover why the cells change and stop it from happening.
"We found that these induced breast cancer stem cells [iBCSC] were generated by radiation-induced activation of the same cellular pathways used to reprogram normal cells into induced pluripotent stem cells [iPS] in regenerative medicine," said Dr. Frank Pajonk, who also is a scientist with the Eli and Edythe Broad Center of Regenerative Medicine at UCLA. "It was remarkable that these breast cancers used the same reprogramming pathways to fight back against the radiation treatment."
This new understanding opens a door for endless possibilities, and could potentially result in a much more effective radiation treatment.
According to the American Cancer Society, breast cancer is the second leading cause of cancer-related death among women, following only lung cancer. However, the death rate has been decreasing since 1990 due to advancements in research and breakthrough breast cancer news.